Non-invasive super-resolution imaging through dynamic scattering media

Abstract Super-resolution imaging has been revolutionizing technical analysis in various fields from biological to physical sciences. However, many objects are hidden by strongly scattering media such as tissues that scramble light paths, create speckle patterns and hinder object’s visualization, let alone super-resolution imaging. Here, we demonstrate non-invasive through based on a stochastic optical localization (SOSLI) technique. After capturing multiple of photo-switchable point sources, our computational approach utilizes the correlation property retrieve an image with 100-nm resolution, eight-fold enhancement compared diffraction limit. More importantly, SOSLI do not only static media, but also dynamic strong decorrelation tissues. Our paves way non-invasively visualize samples behind at nanometer levels detail.